Wisdom Talk: RNA splicing – gates to cancer vulnerabilities - Learning Mall Premium

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Wisdom Talk: RNA splicing – gates to cancer vulnerabilities

RNA拼接——癌症脆弱性之门

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简介

The ‘simple’ process of gene expression, from DNA to messenger RNA (mRNA) and then to protein, is actually not so simple in human cells. Decades of research is leading to a consensus that messenger RNA can have many isoforms as a result of alternative splicing, and then producing protein isoforms for various functions. This maybe a key mechanism driving human cell diversity. In this talk, we will delve into the world the RNA splicing, and find out how can we target this process to inhibitor tumour progression.

基因表达需要经历从 DNA 到信使 RNA（mRNA）再到蛋白质。这一个看起来 “简单” 的过程，实际上却有着非常复杂的细节。随着科学研究的推进，科学家们逐渐意识到信使 RNA 可以有许多相似但又不同的变体，这些变体又可以产生不同功能的蛋白质变体，最终形成各种不同类型的细胞。信使RNA形成变体的这一关键步骤就叫做RNA的可变剪切。这可能是驱动人类细胞多样性的关键机制。在本次演讲中，我们一起学习 RNA 剪切的奥秘，以及如何利用这一点来开发抗肿瘤疗法。